A new method for determination of distribution coefficient of drugs azathioprine. 6-mercaptopurine and 6-thioguanine and nutrient folic acid used in the treatment of inflammatory bowel disease based on a miniaturized shake-flask and HPLC/DAD was developed. Special attention was made to the most commonly reported problems in the measurement of distribution coefficients using a shake-fl... https://www.spidertattooz.com/Masunaga-Tango/